The side looked out of shape as they found the Malians a difficult nut to crack in a one-sided game at Bamako.
It was the second straight defeat the Ghanaian had suffered after Tunisia were awarded
a 20-0 win over the West African country on Saturday night.
The competition itself has produced some amazing upsets and thrills as the journey to the Olympic Games gathers momentum.
On Friday, Mali rolled to a 69-41 win over Tunisia and Senegal trounced Nigeria, 86-62.
On Saturday, Mali won 57-44 over Ivory Coast and Senegal blew away Angola, 63-42.
The stakes are high at the Afrobasket Women because the side that wins will qualify for the London Games.
Mali upset Senegal in the Final played in Dakar four years ago to reach the Beijing Games.
Ivory Coast have lost twice because on Friday, they suffered a 69-65 setback in overtime to Mozambique.
Senegal, who beat Mali in the Final two years ago, only led 32-26 at half-time against Angola on Saturday but pulled away in the second half for a convincing win.
Rwanda, who thrashed Guinea 69-35 in their first game, fell 45-42 to Cameroon on Saturday.
Nigeria, meanwhile, bounced back from their loss to Senegal by defeating Guinea 60-31.
In Monday’s action, Ghana takes on Democratic Republic of Congo while Cameroon face Angola.