The American super star will touched base at the Kotoko International Airport (12:30 GMT) and will be whisked to his hotel.
Bosh will spend four days in Ghana for the second edition of the Sprite Ball Clinic.
He will interact and train promising basketball talents in the country in a platform which will see one player being picked to represent Ghana at the 2014 Basketball Without Borders programme in South Africa.
Bosh is expected to meet with American ambassador to Ghana Gene Cretz on Friday before a scheduled press conference later in the day.
Head of production at Rite Multimedia, Lawrence Nartey Kornor says preparations for the visit of the famous NBA player are well on course.
“We’re ready for Chris. Security and all other details are been looked at,” he told BASKETBALLghana.com
“He is a big player from the biggest league in the world and so we’ll accord him the necessary courtesies that he deserves.
“We’ve had an excellent cooperation with all stakeholders involved including NBA Africa, Coca-Cola Company Limited, Ghana Basketball Association and the American embassy in Accra.
“They are all playing their roles excellently and we hope to have a successful clinic.”
Bosh will train kids at the Aviation Social Centre in Accra on Friday July 11 before travelling to Cape Coast on Saturday July 12 for a similar exercise at the Adisadel College.
Over 100 boys and girls will take part in the clinic which is expected to draw record numbers to the two venues.