The first game has Teshie Rangers taking on Teshie Vikings in all Teshies affair with a lot on the line as both teams lost in Week One.
Vikings, with close ties to Rangers, are making their debut in the league and lost 45-58 to Francophone Stars in its first game.
Rangers lost 47-51 to Tema Community 2; the game tips off at 15:30 GMT right before Akatsi Rifles take on Tema Rockets.
Rifles competed in Week One but lost 46-64 to defending league champions Tema Community 4; Rockets will be playing for the first time this season.
After falling 67-69 in a cliff hanger of a game, Tema Community 2 will be looking for a win against Tema Heat who beat Rangers.
The final game has 2016 League champions Nungua Coldstore set to play its first game in season 2018; Coldstore plays Francophone Stars in the final game of the day.
By Yaw Adjei-Mintah
@YawMintYM on Twitter