The two teams have progressed to the postseason in their first season featuring in the league as Stars clinched the fourth seed and Rangers clinched the eighth seed.
Francophone takes on defending champions Tema Community 4 while Rangers face former league winners Nungua Coldstore who clinched the first seed.
Both sides face uphill tasks against C4 and Coldstore; Nungua lost just a game in 18 appearances in the regular season to top the division.
Despite faltering for much of the season, Community 4 looked dangerous when fully engaged and have the experience of a deep playoff run to bolster its chances.
Francophone shared a ten win, eight loss record with Community 4 but a better goal difference put Francophone ahead of the 2017 winners.
Stars beat C4 39-27 but Rangers lost both games in the regular season to Coldstore.
By Yaw Adjei-Mintah
@YawMintYM on Twitter