The opening game has Tudu Galaxy taking on Junior Reformers at 18:00 GMT before bottom club Teshie Rangers play against Dunk Knights. Galaxy ranks seventh and is one spot below sixth ranked Reformers.
Rangers are yet to win a game this season after three games and lie bottom of the ten team standings with just three points.
Its last league appearance was a humbling 56-101 loss to Tudu Galaxy in a game Rangers had just five players available for selection and ended with two players on the court due to foul trouble.
Dunk Knights head to the game as favorite despite having its winning streak end in Week 3 following a 60-72 loss to league leaders Adabraka CYO.
Games will continue on Saturday, November 10 at the same venue with CYO playing Swanlakers in one of three scheduled fixtures.
By Yaw Adjei-Mintah
@YawMintYM on Twitter