LIR replaced University of Energy and Natural Resources (UENR) after Week 6 following a 23-18 win over the latter at the Eusbett Court in Sunyani.
Royals first test as league leaders is against Desert Rabbits in Week 7; Rabbits is fourth in the league with four wins in six games this season.
LIR must avoid a loss to maintain its position at the summit since close rivals UENR and Suncity Braves have the same number of points (11) heading to the fixture.
Barracks Scorpions will be involved in the first game of the round against West Siders who rank bottom of the standings with five points.
West Siders are yet to win a game this season and forfeited its last matchup against Desert Rabbits.
UENR plays Sunyani Technical University in the third game of the round before Catholic University College, Ghana (CUCG) Saints take on Braves in the final game.
By Yaw Adjei-Mintah
@YawMintYM on Twitter
