West African nations Senegal and Mali face off in the opening game at 14:00 GMT in Lagos, Nigeria after both nations grabbed wins in the opening game.
Senegal secured a 94-89 win over Rwanda and Mali piped Central African Republic 66-65 and the latest chapter in the rivalry happens in a few hours.
After clinching a 65-50 win over Morocco, Tunisia is in another North African derby today as it faces Egypt in what is expected to be a crunch game.
African Champions Tunisia are unbeaten in seven games and look to preserve that against Egypt who beat Chad 99-83.
Cameroon plays Morocco, Rwanda faces Ivory Coast, Chad plays Angola and 2015 African Champions Nigeria take on Central African Republic.
12 teams are battling for Africa’s five slots at next year’s World Cup in the expanded 32 team format.
By Yaw Adjei-Mintah
@YawMintYM on Twitter