Both schools are yet to lose a game with PRESEC-Osu unbeaten in three games while Sacred Heart head to its final game against Adisadel College in Group D.
PRESEC-Osu has ended competing at the group stage of the competition in Group A winning all three games including a big win over Mfantsipim School.
Record winners of the competition, Mfantsipm was embarrassed 14-45 by PRESEC-Osu in the opening game of the tournament.
PRESEC won Group A after beating 2014 winners Keta Senior High School 25-20 and Takoradi Technical Institute 20-16 in the remaining games.
Sacred Heart on the other hand has sealed its place in the knockout phase of the competition heading to its final game against Mawuli Senior High School.
After clinching a big Adisadel College win over defending champions Opoku Ware School on Day One, Sacred Heart beat Mawuli Senior High School 23-8.
In the female division, Awudome Senior High beat St. Mary’s Senior High School 33-16.
By Yaw Adjei-Mintah
@YawMintYM on Twitter